Home / Unlabelled / Tsh Levels And Vitamin D

Tsh Levels And Vitamin D

Tsh Levels And Vitamin D

Abstract

Purpose

The impact of vitamin D supplementation on thyroid function is not clear and the relationship between hypovitaminosis D and autoimmune thyroiditis (ATD) incidence and evolution is still a matter of debate. The aim of this study was to retrospectively evaluate the impact of vitamin D supplementation on thyroid function in subjects with and without ATD.

Methods

One hundred and ninety-eight euthyroid subjects, with diagnosis of "hypovitaminosis D" (<30 ng/mL) who had been taking supplementation therapy with cholecalciferol for different time periods, were included. They were divided in two groups according to the previous diagnosis of ATD: "ATD-neg" group including subjects without ATD [n = 103 (52%)]; "ATD-pos" group including subjects with a confirmed diagnosis of ATD [n = 95 (48%)]. For both groups, we considered TSH and 25 hydroxyvitamin D (25OHD) levels before (T0) and after (T1) cholecalciferol supplementation. We also considered the treatment duration and the monthly dose of cholecalciferol expressed as IU/month.

Results

In hypovitaminosis D subjects with ATD, TSH levels significantly decreased after therapy with cholecalciferol 100.000 IU/month [mean ± SD, TSH at T0: 2.67 ± 1.21 vs. TSH at T1: 2.28 ± 0.86, p = 0.028]. No significant TSH variation was observed in ATD-neg group, irrespective of treatment dose and duration. As expected, 25OHD levels significantly improved with all monthly doses and especially in the group receiving 100.000 IU/month.

Conclusions

Cholecalciferol supplementation improved thyroid function in euthyroid ATD-pos subjects affected with severe hypovitaminosis D. In particular, a significant reduction in TSH levels was observed in subjects with very low baseline 25OHD levels, after taking high monthly doses of cholecalciferol.

References

  1. 1.

    M. Umar, K. S. Sastry, A. I. Chouchane, Role of vitamin D beyond the skeletal function: a review of the molecular and clinical studies. Int. J. Mol. Sci. 19(6), (2018). https://doi.org/10.3390/ijms19061618

  2. 2.

    Y.H. Lai, T.C. Fang, The pleiotropic effect of vitamin d. ISRN Nephrol. 2013, 898125 (2013). https://doi.org/10.5402/2013/898125

    CAS  Article  PubMed  PubMed Central  Google Scholar

  3. 3.

    A. Hossein-nezhad, A. Spira, M.F. Holick, Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. PLoS ONE 8(3), e58725 (2013). https://doi.org/10.1371/journal.pone.0058725

    CAS  Article  PubMed  PubMed Central  Google Scholar

  4. 4.

    T.D. Thacher, B.L. Clarke, Vitamin D insufficiency. Mayo Clin. Proc. 86(1), 50–60 (2011). https://doi.org/10.4065/mcp.2010.0567

    CAS  Article  PubMed  PubMed Central  Google Scholar

  5. 5.

    M.F. Holick, N.C. Binkley, H.A. Bischoff-Ferrari, C.M. Gordon, D.A. Hanley, R.P. Heaney, M.H. Murad, C.M. Weaver, S. Endocrine, Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 96(7), 1911–1930 (2011). https://doi.org/10.1210/jc.2011-0385

    CAS  Article  PubMed  Google Scholar

  6. 6.

    J.E. Manson, P.M. Brannon, C.J. Rosen, C.L. Taylor, Vitamin D deficiency—is there really a pandemic? N. Engl. J. Med. 375(19), 1817–1820 (2016). https://doi.org/10.1056/NEJMp1608005

    CAS  Article  PubMed  Google Scholar

  7. 7.

    F. Baeke, T. Takiishi, H. Korf, C. Gysemans, C. Mathieu, Vitamin D: modulator of the immune system. Curr. Opin. Pharmacol. 10(4), 482–496 (2010). https://doi.org/10.1016/j.coph.2010.04.001

    CAS  Article  PubMed  Google Scholar

  8. 8.

    J. Wang, S. Lv, G. Chen, C. Gao, J. He, H. Zhong, Y. Xu, Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients 7(4), 2485–2498 (2015). https://doi.org/10.3390/nu7042485

    CAS  Article  PubMed  PubMed Central  Google Scholar

  9. 9.

    N.C. Bozkurt, B. Karbek, B. Ucan, M. Sahin, E. Cakal, M. Ozbek, T. Delibasi, The association between severity of vitamin D deficiency and Hashimoto's thyroiditis. Endocr. Pract. 19(3), 479–484 (2013). https://doi.org/10.4158/EP12376.OR

    Article  PubMed  Google Scholar

  10. 10.

    G. Effraimidis, K. Badenhoop, J.G. Tijssen, W.M. Wiersinga, Vitamin D deficiency is not associated with early stages of thyroid autoimmunity. Eur. J. Endocrinol. 167(1), 43–48 (2012). https://doi.org/10.1530/EJE-12-0048

    CAS  Article  PubMed  Google Scholar

  11. 11.

    F. D'Aurizio, D. Villalta, P. Metus, P. Doretto, R. Tozzoli, Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun. Rev. 14(5), 363–369 (2015). https://doi.org/10.1016/j.autrev.2014.10.008

    CAS  Article  PubMed  Google Scholar

  12. 12.

    D. Kim, The role of vitamin D in thyroid diseases. Int. J. Mol. Sci. 18(9) (2017). https://doi.org/10.3390/ijms18091949

  13. 13.

    B. Menon, C.V. Harinarayan, The effect of anti epileptic drug therapy on serum 25-hydroxyvitamin D and parameters of calcium and bone metabolism–a longitudinal study. Seizure 19(3), 153–158 (2010). https://doi.org/10.1016/j.seizure.2010.01.006

    Article  PubMed  Google Scholar

  14. 14.

    B. Ucan, M. Sahin, M. Sayki Arslan, N. Colak Bozkurt, M. Kizilgul, A. Gungunes, E. Cakal, M. Ozbek, Vitamin D treatment in patients with hashimoto's thyroiditis may decrease the development of hypothyroidism. Int J. Vitam. Nutr. Res 86(1-2), 9–17 (2016). https://doi.org/10.1024/0300-9831/a000269

    CAS  Article  PubMed  Google Scholar

  15. 15.

    R. Chahardoli, A.A. Saboor-Yaraghi, A. Amouzegar, D. Khalili, A.Z. Vakili, F. Azizi, Can Supplementation with vitamin D modify thyroid autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and thyroid profile (T3, T4, TSH) in Hashimoto's thyroiditis? A double blind, randomized clinical trial. Horm. Metab. Res 51(5), 296–301 (2019). https://doi.org/10.1055/a-0856-1044

    CAS  Article  PubMed  Google Scholar

  16. 16.

    P. Vahabi Anaraki, A. Aminorroaya, M. Amini, F. Momeni, A. Feizi, B. Iraj, A. Tabatabaei, Effect of vitamin D deficiency treatment on thyroid function and autoimmunity markers in Hashimoto's thyroiditis: a double-blind randomized placebo-controlled clinical trial. J. Res. Med Sci. 22, 103 (2017). https://doi.org/10.4103/jrms.JRMS_1048_16

    Article  PubMed  PubMed Central  Google Scholar

  17. 17.

    A. Talaei, F. Ghorbani, Z. Asemi, The effects of vitamin D supplementation on thyroid function in hypothyroid patients: a randomized, double-blind, placebo-controlled trial. Indian J. Endocrinol. Metab. 22(5), 584–588 (2018). https://doi.org/10.4103/ijem.IJEM_603_17

    CAS  Article  PubMed  PubMed Central  Google Scholar

  18. 18.

    M.T. Cantorna, L. Snyder, Y.D. Lin, L. Yang, Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients 7(4), 3011–3021 (2015). https://doi.org/10.3390/nu7043011

    CAS  Article  PubMed  PubMed Central  Google Scholar

  19. 19.

    M. Barragan, M. Good, J.K. Kolls, Regulation of dendritic cell function by vitamin D. Nutrients 7(9), 8127–8151 (2015). https://doi.org/10.3390/nu7095383

    CAS  Article  PubMed  PubMed Central  Google Scholar

  20. 20.

    M. Sar, W.E. Stumpf, H.F. DeLuca, Thyrotropes in the pituitary are target cells for 1,25 dihydroxy vitamin D3. Cell Tissue Res. 209(1), 161–166 (1980). https://doi.org/10.1007/bf00219932

    CAS  Article  PubMed  Google Scholar

  21. 21.

    L.O. Chailurkit, W. Aekplakorn, B. Ongphiphadhanakul, High vitamin D status in younger individuals is associated with low circulating thyrotropin. Thyroid 23(1), 25–30 (2013). https://doi.org/10.1089/thy.2012.0001

    CAS  Article  PubMed  Google Scholar

  22. 22.

    Q. Zhang, Z. Wang, M. Sun, M. Cao, Z. Zhu, Q. Fu, Y. Gao, J. Mao, Y. Li, Y. Shi, F. Yang, S. Zheng, W. Tang, Y. Duan, X. Huang, W. He, T. Yang, Association of high vitamin d status with low circulating thyroid-stimulating hormone independent of thyroid hormone levels in middle-aged and elderly males. Int. J. Endocrinol. 2014, 631819 (2014). https://doi.org/10.1155/2014/631819

    CAS  Article  PubMed  PubMed Central  Google Scholar

Download references

Author information

Affiliations

  1. Endocrinology Unit, Fondazione Policlinico "Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Largo Gemelli 8, I-00167, Rome, Italy

    Alice Villa, Andrea Corsello, Giampaolo Papi, Alfredo Pontecorvi, Salvatore Maria Corsello & Rosa Maria Paragliola

  2. Scuola di Specializzazione in Scienza dell'Alimentazione, Università di Roma Tor Vergata, Via Montpellier 1, I-00133, Rome, Italy

    Marco Cintoni

Corresponding author

Correspondence to Andrea Corsello.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Verify currency and authenticity via CrossMark

Cite this article

Villa, A., Corsello, A., Cintoni, M. et al. Effect of vitamin D supplementation on TSH levels in euthyroid subjects with autoimmune thyroiditis. Endocrine 70, 85–91 (2020). https://doi.org/10.1007/s12020-020-02274-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI : https://doi.org/10.1007/s12020-020-02274-9

Keywords

  • Vitamin D
  • Hypovitaminosis D
  • Thyroid function
  • Hashimoto's thyroiditis

Tsh Levels And Vitamin D

Source: https://link.springer.com/article/10.1007/s12020-020-02274-9

Tsh Levels And Vitamin D Tsh Levels And Vitamin D Reviewed by Theodore on Desember 01, 2021 Rating: 5

You May Also Like

Tidak ada komentar:

Langganan: Posting Komentar ( Atom )
Diberdayakan oleh Blogger.
banner